The wife of George III was Princess Charlotte of Mecklenburg-Strelitz, in modern-day Germany.
Chase City was named for Salmon P. Chase, a Yankee abolitionist. After the Civil War, nearly 300 Ohions (many of them Presbyterians of German descent) migrated to Southside Virginia and formed the town. Despite the name of Chase City, the community is a town that was chartered by the state in 1873.
Clarksville was named for Clark Royster. His father had come to the area to manage lands acquired by William Byrd II. Clark Royster built a tavern and tobacco warehouse, and in 1818 got the General Assembly to grant a charter for a town. Clarksville was incorporated in 1821.1
the Occaneechi tribe operated a trading depot on an island in the Roanoke River, and Nathaniel Bacon raided it during his rebellion in 1676
Source: University of North Carolina, A Compleat map of North-Carolina from an actual survey (by John Collet, 1770)
One major employer in the county today is Microsoft. It opened a data center there in 2010. In 2019, it announced its sicth expansion of that facility.2
Mecklenburg County in the 1870's
Source: Library of Congress, Virginia: Mecklenburgh (by Jedediah Hotchkiss, 1870's)